ABSTRACT
With the SARS-COV-2 spreading worldwide, COVID-19 has induced enormous disaster and challenges to the world public health since 2019. To development effective diagnostic and treatment methods for the SARS-CoV-2 is crucial for the control of the COVID-19 spreading. DNA aptamers, short single DNA oligonucleotides, have shown an immense application potential as molecular probes for early diagnosis and therapy of various diseases. Compared with antibodies, DNA aptamers are easier to synthesize, with high stability and low immunogenicity, which allows it to be widely and rapidly used in various bio-sensing and therapy to against COVID-19 since then. Thus, we here reviewed the development and prospected potential applications of DNA aptamers in diagnosis and treatment of SARS-COV-2.